After years of the oil company fracking, an earthquake ensues in New Orleans, unleashing giant subterranean, fire breathing, carnivorous spiders with an appetite for human eyeballs. 30 year old slacker tour bus driver, Paul, must lead his group to safety into the swamps of Louisiana when the bus (and town) is over run by the deadly arachnids. It is here the group discovers the spiders can run across water, and the hive with the queen.