E along with his friend Tony (Karunas) carry out petty crimes to earn money. Raised in harsh conditions, he grows up tough, fearless and emotionless. In the meantime; Dr. Ramakrishnan (Ashish Vidyarthi), a charlatan, comes to the slum and projects himself as a benefactor to the people living there. Unaware of his ulterior motives, the slum dwellers maintain an unwavering faith in him. However, his hidden agenda is to use them as guinea pigs to test his new but potentially lethal medicines. And he saves Doctor Ramakrishnan from Nellai Mani (Pasupathy), a terrorist, who is after the Doctor to kill him. Realizing E's audacity, the Doctor enters into a pact with E to capture Mani for a large sum. E he captures Mani and when he takes him to deliver him to the doctor. Mani tells of Ramakrishna's evil designs. The rest of the movie is about how E thwarts the doctor's malicious actions and drives him to the books.