God of Gamblers is a story about Do San, a legendary gambler known for his supernatural abilities. He agrees to help a friend settle a debt by defeating his friend's adversary in a card game.
Despite having a bodyguard assigned to him, Do San experiences a tragic accident that results in him losing some of his memories and regressing to a childlike mental state. Knife, a small-time hustler, along with his girlfriend, take care of Do San as they feel responsible for his accident.
As time passes, they realize that Do San still possesses some of his gambling powers and decide to take him to local gambling halls. However, they soon find themselves being chased by Knife's loan shark and enemies from Do San's past.
A final showdown is set to take place at the card tables, where Do San's true abilities as the God of Gamblers will be put to the test.