Guddu Ki Gun is the story of Govardhan, also known as Guddu (Kunal Kemmu), a Bihari based in Kolkata. He is a door-to-door washing powder salesman whose sales pitch is "Ek washing powder ke saath Guddu free". Sharing a room with his close friend Ladoo (Sumeet Vyas), Guddu leads a loving lifestyle in Kolkata. His tribulations begin when one of his girlfriends, Bholi (Aparna Sharma), is dumped. Furious at having abandoned her granddaughter, Bholi's grandfather casts a black magic spell on her. The only way Guddu can get rid of the curse is to find true love and stay true to her.