A young heroic doctor in the jungles of Thailand attempts to rescue a beautiful girl from being sacrificed to the "Worm Tribe" she belongs to. As a result, the doctor is damned with seven "Blood Curses" that burst through his leg periodically. When the seventh bursts, he will die, but Betsy, the beauty he saved stops the curse with an antidote that lasts only one year, so on the advice of Wisely (Chow Yun Fat) he heads back to Thailand to find a permanent cure.
Action ensues as the doctor and cohorts battle the evil sorcerer of the Worm Tribe, a hideous bloodthirsty baby like creature, and "Old Ancestor," a skeleton with glowing blue eyes that transforms into a monster that is a cross between Rodan and Alien.