This Guy's in Love with U, Mare! is about an unlikely love triangle. When Lester (Vice Ganda) catches his boyfriend Mike (Luis Manzano) proposing marriage to Gemma (Toni Gonzaga), it seems as if Lester's whole world is crashing down. Lester devises what he thinks is a brilliant plan to keep Gemma away from Mike by getting her to fall in love with him instead. Will Lester succeed in re-winning Mike's heart?