1961: When Abby Hedley (Marian Seldes) dies of a stroke, her surviving partner of fifty years, Edith Tree (Vanessa Redgrave), must silently face heartbreak and the denial of her status as "family" by the hospital and Abby's heirs.
1972: Feminist and college student Linda (Michelle Williams) and her lesbian cohorts are ousted from the on-campus women's group - apparently, the cause of feminism comes first. Attempting to forget their troubles, the friends go to the town's only lesbian bar, where Linda meets Amy (Chloë Sevigny), who is too butch for Linda's friends. Intrigued, despite her friends' disapproval, Linda comes to understand and fall in love with Amy while learning about her own prejudices.
2000: Fran (Sharon Stone) and Kal (Ellen DeGeneres) want to have a baby. But they want the baby to be theirs only, so to the sperm bank they go. But the decisions to be made. Ordering over the internet? Which donor? What race? What gender? And what if the sperm bank is out of that particular perfect donor? Above all, is it right to bring a baby into a world that will undoubtedly be prejudiced? Or will love and laughter see them through?