"Difficult People" is a comedy series that follows the lives of two best friends, Julie and Billy, who are struggling to make it in the entertainment industry in New York City. Julie is a struggling comedian and Billy is an aspiring actor, both of whom are known for their sarcastic and cynical personalities. Despite their close friendship, they often find themselves in awkward and hilarious situations as they navigate their way through the competitive world of show business. The series explores themes of friendship, ambition, and the challenges of pursuing one's dreams in a city that can be both inspiring and unforgiving.