Marked Man tells the story of Frank Stanton (Roddy Piper), a man who is imprisoned for killing the drunk driver responsible for his fiance's death. While behind bars, Stanton witnesses the murder of a fellow inmate by two guards.
Realizing that he has been seen, the guards open fire on Stanton, forcing him to escape the prison. Now considered a "marked man," Stanton must clear his name and evade a manhunt that is determined to take him down.
As Stanton goes on the run, he uncovers a conspiracy involving the prison guards, the murdered inmate's wife (Alina Thompson), and security agency owner Vince Malick (Miles O'Keeffe).
Stanton must now battle Malick and his dangerous henchmen in order to prove his innocence and save his own life.