Mujeres Asesinas shows the dark side of women who have been mistreated or abused and have become cruel murderers. The series shows how violence and death can overcome the feminine mind. Each episode shows a different story of a woman who has committed homicide. These women are motivated by multiple passions such as love, hatred, resentment, vengeance, lunacy, despair, fear, anger, addiction, salvation, and redemption. Dr. Sofía Capellan and her team of experts try to solve the murders perpetrated by the women.