Run with the Hunted is a story about Oscar, a young boy who defends his best friend, Loux, and ends up killing her abusive father. This tragic event forces Oscar to flee from his rural hometown, leaving his innocence behind.
As Oscar grows older, he is introduced to love, crime, and corruption, which shape him into a hardened individual. Fifteen years later, he has become the leader of a band of lost children, having almost forgotten his past.
Meanwhile, Loux moves to the same city in search of a better life and finds a job working for a private investigator. When she comes across Oscar's missing child report from years ago, she takes it upon herself to find the boy who once saved her life.