Sam Puckett has been touring the West Coast by motorcycle, and stops in Los Angeles. She witnesses Cat Valentine being thrown into the back of a garbage truck, and rescues her. They become friends, and Cat convinces her to become roommates after Cat's grandmother moves to a retirement home. To make money, rather than getting traditional after-school jobs, they form an after-school babysitting business that leads them into a series of comical adventures. Also involved in their lives are Dice, their next-door neighbor, who is notorious for aiding people for money; Cat's cheerful, supportive grandmother Nona, who decided to move into the "Elderly Acres" home for the aged; and Goomer, a dim-witted professional MMA fighter whom Dice manages.