It is the year 1788, during the Tenmei era, a time of famine and disaster. Things get bad quickly when Amakusa Shirou Tokisada, a Japanese Christian who was killed during an unsuccessful attempt to kill Tokugawa over a hundred years ago, has been resurrected. Now he wants to take over Japan. When hearing of this, 12 of the best samurai, ninja, and warriors from around the world go to Japan to stop Amakusa.