Slime City is the story of Alex, an art student just trying to get some. He rents an apartment from a seemingly sweet old Lizzie to try to sway his girlfriend Lori into 'sleeping' over.
Roman and Nicole, the building's other two youth residents take more than a healthy interest in our boy. Nicole practically says 'Come up and plow me sometime' and Roman has him over for green pudding and haunted Crème de Methe. Roman explains the goo is Himalayan yogurt made by Lizzie and the wine is made by her dead alchemist father Zachary.
Staggering back to his apartment, Alex runs into Nicole. Then they take off their pants and run into each other a few more times. Alex wakes up the next morning covered in slime or possibly melting. He decides to go out for tea and murders a hobo. Before the hobo's blood is dry, Alex is back to normal.
Roman brings by some more goo and Alex hoovers it up. Afterwards, he meets Lori's parents and ruins dinner with the revelation that he no longer wants to move in with him. He starts to get slimy again and slashes up a prostitute.
Finally getting fed up with the slime cycle, Alex confronts Lizzie and Nicole. They reveal he is being fed an elixir and ectoplasmic primer to allow dear, dead dad, Zachary to take over his body. The rest of Zach's former cult have taken up residence in Roman, Nicole and neighbor Ruby.
Alex swears off the junk, reconciles with Lori and they have sex. Unfortunately, Zachary's hostile takeover is nearly complete and he attacks Lori. Despite no longer being a virgin, Lori hacks Alex into squirmy little bits and saves herself. After the police investigation, Ruby and Lizzie are attempting to rent Alex's old place to the detective on the case.