Zoe, Duncan, Jack & Jane
This series saw two lives. First: The first series follows four students (see title of show) at a private high school in Manhattan, Fielding Mellish Prep. Even in the first series, the show focus was on Zoe (Selma Blair). The other kids in the title are her friends: loser Duncan (David Moscow) and twins Jack (a pre-Lex Luthor Michael Rosenbaum) and Jane (Azura Skye). The first series lasted 13 episodes before being halted for a remix.
Second: The second series was just called "Zoe" and follows Zoe a few years later as a college student studying psychology. Most of the characters from the first 13 episodes turn up in the second "Zoe" 13 episodes.