A.P. Bio is a comedy series that follows a disgraced Harvard philosophy scholar, Jack Griffin, who is forced to return to his hometown of Toledo, Ohio to teach Advanced Placement Biology at Whitlock High School. Despite his lack of interest in teaching, Jack sees this as an opportunity to get revenge on his rival, Miles Leonard, who is now the school's principal.
Throughout the series, Jack enlists the help of his students to carry out his elaborate schemes, all while trying to avoid actually teaching them biology. Despite his initial intentions, Jack begins to form a bond with his students and learns valuable lessons about life and friendship along the way.
A.P. Bio is a hilarious and heartwarming show that explores the unconventional relationships that can form between teachers and students, and the importance of finding purpose and connection in unexpected places.