Stacked follows the story of Skyler Dayton, who is tired of her non-stop partying lifestyle and bad choices in boyfriends. Seeking a major life change, she stumbles upon "The Stacks," a small family-run bookstore owned by Gavin Dewitt and his brother, Stuart.
Divorced and unlucky in love himself, Gavin sees Skyler as a representation of the vacuous, image-obsessed culture he despises. On the other hand, Stuart is captivated by Skyler's beauty and offers her a job at their store, much to Gavin's dismay. Skyler gladly accepts the job as a first step towards a more stable lifestyle.
Working alongside Skyler is the store's other employee, Katrina, who is unhappy about having to work next to such a striking beauty. Katrina brings doses of realism and cynicism to the dynamic. The store's one steady customer is Harold March, a retired rocket scientist.