Dominion tells the story of a world where God vanishes and the archangel Gabriel and his army of lower angels wage war against mankind, blaming them for God's absence.
Twenty-five years later, humanity survives in a few fortified cities. The Archangel Michael has chosen to side with humanity against Gabriel, living among humans in the fortified city of Vega (formerly Las Vegas).
As Michael fights against his brother Gabriel in support of humanity, the politics of Vega struggle to maintain peace in the ongoing war.
Alex, a young soldier in the V system of Vega, is revealed to be the chosen one. He bears the markings, the last message from God. Saved by Michael as a baby and abandoned by his father, Alex had to overcome struggles in the lower class before succeeding in the military.
The chosen one faces a crucial decision: to save both the human race and the angels, or to destroy them all.