Only a few weeks after the devastating events in Resident Evil: Retribution (2012), Professor James Marcus makes a breakthrough by discovering the T-Virus: a miraculous remedy designed to treat his young daughter Alicia's Progeria, a fatal malady.
Instead, the cure brought the entire world to its knees within hours. Under those grave circumstances, Alice must race the clock and break back into the ruined Umbrella Corporation Headquarters in Raccoon City to retrieve the last phial of anti-virus.
However, the impenetrable Hive is swarming with ferocious monstrosities. And as if that weren't enough, Dr Alexander Isaacs, Alice's megalomaniac arch-nemesis, has a mad hidden agenda.
Is all hope lost?