"The Cherokee Kid" is a story about Isaiah, whose family is destroyed by the greedy land-grabber, Bloomington. Despite knowing nothing about the world, Isaiah vows to someday get revenge. He is forced to rob a bank and captures the gang, learning about good and evil in the process.
Isaiah learns how to live off the land from Otter Bob, known as the "Best Mountain Man in Texas". He discovers the values of friendship and loyalty after saving the life of Cortina, the "Hero of the Mexican People". He also learns how to shoot from Nat Love and about love from Stagecoach Mary.
The climax of the story comes when Isaiah faces a showdown with the notorious Undertaker, who is working for Bloomington. Rumors suggest that The Undertaker may have killed Isaiah's brother, Jedediah, making the situation even more intense.