Two Days with Juliet tells the story of a troubled young girl, Juliet, who is a self-injurer. She cuts herself to relieve the pressures of stress, anger, and depression. Upon her mother's death, Juliet inherits a local boarding house and heads there to learn who her mother really was. Upon arrival, Juliet learns her mother's dark secret, which throws her deeper into her depression, and cutting. With the help of a recovering drug-addict, Pete, the wise-old housemother, Irene, and Juliet's suicidal younger sister, Jenna, Juliet struggles to cure her cutting tendencies while battling her mother's secret history.