Up, Down, Fragile is a story about three young women spending a hot, lazy summer month in Paris, the City of Love.
Ninon, a streetwise whore, leaves her worthless friend and takes a job with a courier company. She is obsessed with dancing and spends a lot of time in a nightclub run by the mysterious Alfredo Garcia.
Louise, who has emerged from a five-year coma, takes a room in a hotel and finds out that her aunt has died and she has inherited her house.
Ida is a librarian in a beautifully-decorated reading room. She is torn apart by the fact that she is an adoptee and obsessed by an old pop melody that may be the key to the identity of her parents.
These three characters are linked by the figure of Roland, a friend of Louise's deceased aunt who often visits the library where Ida works and who falls in love with Ninon.
As the characters' lives become more intertwined, the past throws its shadow over the present and the characters are forced to formulate their views on and their desires for life.