Once again, the City Hunter team finds themselves in hot water as they get caught up in a hostile takeover involving a Central American dictator named General Gillium who has just been overthrown from his country and has been in hiding.
But Gillium refuses to accept this and with a band of soldiers carrying high-tech weaponry, he takes over the Bay City Hotel during it's grand opening and to make matters worse, Kaori and Miki are present.
Meanwhile, a starving Ryo is wandering the streets of Shinjuku trying to find a bite to eat when he suddenly runs into a lovely young woman named Luna, who for reasons unknown, is being staked out by Falcon, Ryo's rival.
When Luna escapes his clutches and accompanies her father to the hotel, the plot begins to fit together.
It seems that Luna is an expert hacker with advanced intelligence in computers and she plans to use the hotel's central computer system to launch a nuclear strike against the U.S. in retaliation for her father's coup de tat.
Now, it's up to Ryo and Falcon to free the hostages from the hotel and prevent a nuclear holocaust from wiping out the U.S.
Will they succeed in freeing Kaori, Miki and the others in time?
Will they be able to keep the U.S. from disappearing off the map?
But most of all, can Ryo ignore his sensation for 'nookie' long enough to realize that Luna is the enemy?