While a terrorist epidemic strikes the world leaders, the commissaire San-Antonio and his partner Lieutenant Bérurier must escort the French ambassador to a British hotel. But after a negligence of Bérurier (one more little sex affair), San-Antonio powerlessly witnesses the ambassador's abduction, organized by a gorgeous Italian girl. Back in Paris, San-Antonio is dismissed by Police Chief Achille Hachille, which is a real godsend to Bérurier, who gets promoted. But the situation soon degenerates when the president of the Republic mysteriously disappears. Immediate reaction from the Police Minister: only San-Antonio can save the day; he has 48 hours and a secret squad to find the president. At the Elysée, San-Antonio finds Bérurier, the official investigator. But now, it's every man for himself: who will be the first to find the President? There are multiple trails: terrorists, unscrupulous banks, international dealers, dishonest politicians, and pretty women with very convincing arguments.