Blade is a hybrid vampire who prowls the vampire underworld in nightclubs and dark streets of New York City, fueled by his hatred for the vampires who killed his mother during childbirth. He is aided by his weapons manufacturer, Abraham Whistler.
When Blade encounters a Hematologist who has been bitten by one of his enemies, he takes her to his lair where she meets his friend who provides her with an antibiotic to slow the spread of vampire blood in her body. After freeing her, Blade realizes she is still in danger and discovers that she may hold the key to creating a cure for his bloodthirsty condition.
Together, they embark on a mission to stop the bloodthirsty Deacon Frost, a turned vampire, from summoning the evil spirit of La Magra, a Blood King who threatens to unleash an army of vampire spirits on New York City and beyond.